Overall, it was determined that inhibition of Axl and MerTK by INCB081776 led to a more “antitumor” TIME, ushering in a new era for our team to determine how Axl and MerTK contribute to an immunosuppressive and immunoevasive TIME in HNSCC [71]. The gene discussed is AXL; the disease is head and neck squamous cell carcinoma.