Those mentioned in Table 1 are the simplest and most practical indices, but for a more complete diagnosis, there are also other interesting biomarkers that are related to IR/Hyperin, including respiratory metabolites to assess systemic metabolic dysregulation [23], serum levels of molecules potentially related to cognitive decline (βA42 and PSEN1) [24], adiponectin [25], and the inflammation marker NHR (Neutrophils to the HDL/Cholesterol Ratio Index) [26]. This evidence concerns the gene PSEN1 and Mental deterioration.