Based on the existing literature, these mRNAs were associated with gastrointestinal tract barrier function (four mRNAs: BATF3, CCR6, CXCR6, and PDCD2), gastrointestinal immunity (four mRNAs: CLEC5A, IL7, CARD9, and FCER1G), and future risk of IBD (eight mRNAs: PD-L1, CSF1R, FAS, BID, FADD, GATA3, and KIR3DL). Here, CARD9 is linked to inflammatory bowel disease.