Different phenotypes of the killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (KIR3DL1) gene are associated with susceptibility to IBD [45]; however, according to the published literature, it is unknown if transient changes in KIR3DL1 mRNA expression directly contribute to preventing IBD. Here, KIR3DL1 is linked to inflammatory bowel disease.