Mutations in type 2 ryanodine receptors (RyR2) may lead to cardiac arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia and arrhythmogenic cardiomyopathy [238,239,240], and to cognitive dysfunctions, such as Alzheimer’s disease [241]. Here, RYR2 is linked to early-onset autosomal dominant Alzheimer disease.