The autonomic imbalance induced by emotional and/or physical stress could also result in hypertension, increased afterload, and, ultimately, congestive heart failure (HF) by impairing endothelial signaling, mean arterial pressure, cardiac phenotype and function (e.g., left ventricular hypertrophy and arrhythmia) and the renin–angiotensin–aldosterone system [5,8]. Here, REN is linked to hydrops fetalis.