AGER and type 1 diabetes mellitus: Therapeutic strategies that improved hippocampal-dependent learning and memory by boosting NMDAR signaling and ameliorating LTP impairment in T1DM include the nerve-protective drug extracted from the seed of Chinese celery, l-3-n-Butylphthalide (NBP) [184], the isoquinoline alkaloid berberine [185], the phenolic compound vanillic acid [186], probiotics treatment [187], inhibition of the receptor for advanced glycation end products (RAGE) with the specific blocker FPS-ZM1 [188], physical exercise [189], and stem cell transplantation [190].