The subsequent dimerization and activation of the CSF-1R plays a critical role in recruiting and polarizing macrophages toward the M2 phenotype, due to the activation of downstream signaling pathways such as the phosphatidylinositol 3 kinase (PI3K)/AKT/forkhead box protein O1 (FOXO1) pathway, favoring tumor progression [37,38]. This evidence concerns the gene CSF1R and neoplasm.