The authors developed an in vitro vascularized tumor model to study TAM recruitment and the impact of immunotherapy based on a multispecific CSF-1R/CCR2/TGF-β antibody in breast and lung cancers, and their results demonstrated that the CSF-1R is crucial for recruiting monocytes to the tumoral area while also mediating their pro-tumorigenic M2-like phenotype shift [44]. This evidence concerns the gene CSF1R and lung carcinoma.