CSF1R and cancer: Finally, an interesting study performed on mice delved into the intriguing process of B cell-to-macrophage transdifferentiation, as it revealed that B cell precursors, particularly CSF-1R+Pax5Low pre-B and immature IgM+ B cells (BMBPs), possess remarkable plasticity, enabling them to differentiate into macrophages, which was proven as a mechanism exploited by cancer cells to generate immunosuppressive TAMs.