CD8A and neoplasm: Their dual-inhibitor-loaded supramolecular nanoparticle system exhibited the sustained inhibition of CSF-1R and MAPK signaling pathways, leading to TAM repolarization over time in both in vivo and in vitro models, while also allowing for an increased infiltration of CD8+ T cells in the TME, enhancing the anti-tumor effect of TAM repolarization [48].