TGFB1 and neoplasm: Nonetheless, later phases are dominated by M2-like TAMs, which exhibit pro-tumoral and anti-inflammatory features [34]; in fact, M2-like TAMs exert immunosuppressive functions by releasing an array of anti-inflammatory and pro-tumoral cytokines such as Arginase 1 (Arg-1), transforming growth factor β (TGF-β), IL-6, and IL-10, and contribute to tumor spreading and angiogenesis, thereby supporting tumor progression [35,36].