The therapeutic inhibition of the CSF-1R to mediate TAM depletion was evaluated in a very recent study where a photodynamic self-assembly drug composed of CSF-1R inhibitor BLZ945 and chlorin e6 was used to deplete TAMs, reversing the immunosuppressive TME and enhancing the efficacy of photodynamic immunotherapy, which overcomes the nonimmunogenic tumor phenotype and promotes systemic anti-tumor responses [57]. Here, CSF1R is linked to neoplasm.