Although direct studies on APOE and peritoneal fibrosis are lacking, related genetic mechanisms, such as the role of the enhancer of zeste homolog 2 (EZH2) in regulating TGF-β signaling pathways, suggest a connection between APOE’s functions in inflammation and the lipid metabolism and its potential influence on fibrosis [166]. The gene discussed is EZH2; the disease is Peritoneal Fibrosis.