BRCA1 and cancer: Chiarelli et al., in a study in 2020, which included 8782 women, found that among high-risk women aged 50 to 69, early cancer detection was most effective when mammography was included in an annual breast MRI, while for younger women between the ages of 30 and 39, an annual breast MRI was sufficient as a method, especially for BRCA1 and BRCA2 mutation carriers [16].