In pancreatic cancer cells, IL-1α, through the mitogen-activated protein kinase (MAPK) cascade, stimulates the expression of IL-8 by activating ERK-1/2, p38 MAPK, activator protein-1 (AP-1), and nuclear factor kappa B (NF-κB) [13]. The gene discussed is CXCL8; the disease is familial pancreatic carcinoma.