PLCB1 and Cognitive impairment: In murine models, SZ-like behavior has been documented in phospholipase C β1 (PLCβ1(−/−)) knockout mice, such as hyperlocomotion, decreased exploration, nesting behavior, impaired working memory, and cognitive impairment, possibly due to abnormal cellular plasticity as a consequence of gene deletion and reduced mRNA and protein [50,51].