ADR signaling affects cytokines and immunity (↑TGF-β, ↓pro-apoptotic cytokine and NK cells), tumor-associated macrophages (macrophage M2 polarization), tumor microenvironment status (↑CAF, proinflammatory cytokines, and modulation macrophage M2), oncogenic pathway status (ARRB1, PKA, and oncogene Src activation, and hTERT expression) contributing to cancer progression [22,27]. The gene discussed is ARRB1; the disease is neoplasm.