Median serum levels of insulin activity among subjects with PCOS and obesity (15.90 (11.34; 26.04) uIU/mL) are higher than among control subjects (7.10 (5.52; 9.69) uIU/mL; p < 0.0001; Figure 3I). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.