“APL-like” or “double-negative” (DN) (CD34− HLA-DR−) NPM1m AML can be challenging to distinguish from acute promyelocytic leukemia (APL) before obtaining results of FISH or PCR for RARa-fusions, as both entities share a similar immunophenotype and may present with Auer rods in peripheral blood leukemic cells. Here, RARA is linked to acute promyelocytic leukemia.