To investigate if the two entities APL and “APL-like” NPM1m AML can be distinguished based on hematologic parameters, before obtaining the result of RARa translocations, we collected values for total leukocyte count (WBC), fibrinogen, D-dimers (DDs), and prothrombin time (PT) at diagnosis. The gene discussed is F2; the disease is acute promyelocytic leukemia.