This last report raises the question if there are other AML types, aside from AML with NPM1 mutation, that can be “double-negative”; the article itself reveals that over two-thirds of cases of “double-negative” AML were NPM1-mutated and that over 95% of cases had normal karyotype, but does not specify the exact diagnoses in the DN-AML cases which allegedly did not carry NPM1 mutation. This evidence concerns the gene NPM1 and acute myeloid leukemia.