EGFR and non-small cell lung carcinoma: Our study shows that Def induced cellular iron-depletion, the downregulation of RR and ABCB1 genes, the downregulation of EGFR protein, G0/G1 cell cycle arrest, the disruption of mitochondrial membrane, an increase in reactive oxygen species (ROS), the induction of ferroptosis, a decrease in cell migration area, and the upregulation of the NDRG1 in A549 NSCLC cells.