When cirrhosis was defined as the exposure, the estimates from the IVW method showed that the progression of cirrhosis was significantly associated with increased levels of hepatocyte growth factor (HGF), MIP1β, SDF1α, IL-12, MCP3, and SCF and with decreased levels of IL-2RA, IL-5, IL-7, and TNF-β, which provided supportable evidence for our primary study. This evidence concerns the gene IL2RA and Cirrhosis.