According to our MR analysis, estimates from the MR-IVW method suggest that IP-10 is associated with a reduced risk of cirrhosis (OR = 0.707, 95% CI = 0.516–0.969; p = 0.031), and the same result was obtained in the validation set (IVW-OR = 0.741, 95% CI = 0.684–0.802; p < 0.001). Here, CXCL10 is linked to Cirrhosis.