A heatmap of the MR analysis methods for the association between 41 circulating cytokine levels and the risk of cirrhosis is displayed in Figure 3A. No evidence of pleiotropy in the associations of MCP3, IP10, or IL-1RA was observed, as measured using the MR-Egger intercept (p = 0.090, p = 0.609, p = 0.690), and no outlier SNPs were detected using the MR-PRESSO method. This evidence concerns the gene CCL7 and Cirrhosis.