In the same way, Wakabayashi et al. have published a study showing that the hypermethylation of the p16 gene rather than the p16 protein in astrocytoma is associated with the loss of function of the CDKN2A gene, and through this, the prognosis of glioma can be predicted [39]. The gene discussed is CDKN2A; the disease is astrocytoma (excluding glioblastoma).