In the present study, we performed a GWAS to assess the effect of DH on POAG in the Korean population and identified several novel candidate loci (rs62463744 in TMEM270;ELN, rs11658281 in CCDC42, rs77127203 in PDE10A;LINC00473, rs7589033 in THADA) related to DH. The gene discussed is THADA; the disease is open-angle glaucoma.