TYR and albinism: The complex allele [c.575C>A p.(Ser192Tyr); c.1205G>A p.(Arg402Gln)], and even more so [c.575C>A p.(Ser192Tyr); c.1185-6208A>G; c.1205G>A p.(Arg402Gln)], is either a hypomorphic allele in a compound heterozygous state with a pathogenic variant, or a marker haplotype, on which a relatively recent mutational event in the regulatory regions of the TYR gene has occurred, leading to albinism.