MAP1LC3B and lung adenocarcinoma: Table 1 indicates that among the 91 autophagy-related genes, 11 genes of CD44+A549 cells were up-regulated, and 10 genes were down-regulated compared with A549 cells. From the volcanic map of Figure 5B, mRNA of TGM2 expression was the most up-regulated (p < 0.001). Subsequently, a bioinformatics analysis was used to analyze TGM2. The results showed that there was a certain correlation between TGM2, CD44, and LC3B in lung adenocarcinoma cells (Figure 6A). Figure 5C shows that the protein expression of TGM2 increased in the two cell lines exposing 2 Gy C-ions and 4 Gy X-ray radiation.