To our knowledge, this is the first study to determine the roles of miR-199a-3p, hsa-miR-1-3p and hsa-miR-125b-5p in progesterone resistance in endometriosis via targeting SCD, TAOK1, DDIT4, LASP1, CDK6, TAGLN2, G6PD and ELOVL. This evidence concerns the gene DDIT4 and endometriosis.