EDNRB and cancer: The immune checkpoint inhibitory genes are found to affect various cancer types among different clusters, including BLCA, BRCA, CESC, ESCA, GBM, HNSC, KIRP, KIRC, KICH, LUAD, LUSC, LIHC, OV, PRAD, PCPG, STAD, SKCM, THCA, and UCEC; CD274, CD276, EDNRB, VEGFA, and VEGFB are the most affected tumor types (Figure 7C).