METTL3 and cancer: Our results reveal that the m6A regulators are highly expressed in most of the cancer types, such as CHOL, ESCA, GBM, HNSC, LGG, LAML, PAAD, and STAD, while they are decreased in a few tumor types, including ACC, KICH, OV, THCA, and UCS; METTL3, YTHDC1, YTHDC2, RBM33, and RBFOX2 are preferably lower expressed, while CBLL1, RBM15, RBM15B, METTL5, TRMT112, YTHDF1, YTHDF2, YTHDF3, HNRNPC, HNRNPA2B1, IGF2BP1, IGF2BP2, IGF2BP3, PRRC2A, LRPPRC and FXR1 are highly expressed in most tumor types (Figure 1D).