Interestingly, the methylation levels of most of the RNA m6A regulators are negatively correlated with their mRNA expression in different cancer types, especially METTL5, YTHDC1, VIRMA, FXR1, YTHDF2, and CBLL1 in TGCT; IGF2BP3 and IGF2BP2 in LUSC, HNSC, and PAAD; and IGF2BP2 in THCA and LAML; and YTHDF3 in UCS (Figure 3G). This evidence concerns the gene YTHDF3 and pancreatic adenocarcinoma.