The negative correlation between some genes and some kinds of genomic heterogeneity types in some cancer types is more significant than others, such as METTL5 and LOH in ACC; IGF2BP2 and purity in BLCA; METTL14, METTL16, METTL3, YTHDC2, and ZCCHC4, and HRD and LOH in BRCA; YTHDF1 and TMB, MSI, and NEO in COAD; PRRC2A, RBFOX2, RBMX, WTAP, YTHDC1, and YTHDF2, and LOH in KIRC; IGF2BP3 and MATH in LGG; WTAP and purity in LIHC; METTL14, and YTHDF3, and MSI in PRAD; HNRNPC, and RBFOX2 and LOH in THCA; and ALKBH5 and HRD in TGCT (Supplementary Figure S9). The gene discussed is METTL3; the disease is cancer.