The immunostimulators affect various cancer types among different clusters, including BLCA, BRCA, CESC, ESCA, GBM, HNSC, KIRP, KIRC, KICH, LGG, LUAD, LUSC, LIHC, OV, PRAD, READ, STAD, THCA, TGCT, and UCEC; CD28, ENTPD1, IL6R, NT5E, PVR, TMEM173, TNFSF15, TNFSF18 and TNFSF4 are affected in most tumor types (Figure 7A). This evidence concerns the gene CD28 and cancer.