Some of the immunostimulators are positively correlated, while a few are negatively correlated with the high-risk group in various cancer types; CD276, MICB, PVR, TNFSF4, and ULBP1 in most tumor types are elevated, while C10orf54, CXCL12, ENTPD1, IL6R, NT5E, RAET1E, TNFSF13, and TNFSF15 in KIRC, and IL6R, TMEM173, TNFRSF14, and TNFSF15 in LUAD are the most significantly reduced in the high-risk group (Figure 7B). The gene discussed is CXCL12; the disease is cancer.