The expression of some of the regulators is found to be affected by the tumor N feature in COAD, HNSC, KIRP, KICH, LUSC, PRAD and THCA, especially ALKBH5 and IGF2BP2 in THCA, and FXR1 and IGF2BP3 in KIRP (Figure 2F); and the tumor M feature in ACC, KIRC, and LUAD, especially IGF2BP2 and IGF2BP3 in KIRC, and IGF2BP3 in KIRP (Figure 2G). This evidence concerns the gene IGF2BP3 and neoplasm.