While some immune checkpoint inhibitory genes are positively correlated, some are negatively correlated with the high-risk group in various cancer types; most immune checkpoint inhibitory genes in LGG and LIHC are increased while those in KIRC and PAAD are decreased, especially VEGFA and C10orf54 in KIRC in the high-risk group (Figure 7D). The gene discussed is VEGFA; the disease is cancer.