Our results demonstrate that the chemokines affect various cancer types among different clusters, including BLCA, BRCA, ESCA, HNSC, KIRP, KICH, LUAD, LUSC, LIHC, PRAD, STAD, SKCM, THCA, TGCT, and UCEC; some chemokines affect some cancer types quite significantly, such as CX3CL1, CXCL9, CXCL12, CXCL13 and CXCL16 in HNSC; CXCL12 in KIRC; CXCL8 in LUSC, CXCL8, CXCL9, CXCL10, CXCL11, CXCL12, and CXCL16 in PRAD; and CXCL12 in THCA (Figure 7A). The gene discussed is CXCL16; the disease is cancer.