A few genes have a bad OS disadvantage, such as METTL3 in PAAD; METTL14 in KIRC, SKCM, and READ; METTL16 in CESC and PAAD; WTAP in SKCM; VIRMA in SKCM; ZC3H13 in KIRC; CBLL1 in KIRC; RBM15 in KIRC and READ; RBM15B in KIRC; METTL5 in OV; TRMT112 in OV; ZCCHC4 in KIRC and SKCM; FTO in KIRC; ALKBH5 in ESCA, OV, and PAAD; YTHDC1 in KIRC; YTHDC2 in COAD, KIRC, and READ; and YTHDF1 in READ (Supplementary Figure S3). The gene discussed is YTHDC1; the disease is pancreatic adenocarcinoma.