The immune checkpoint stimulatory genes affect various TCGA cancer types among different clusters, including BLCA, BRCA, CESC, ESCA, GBM, HNSC, KIRP, KIRC, LGG, LUAD, LUSC, LIHC, OV, PRAD, PAAD, PCPG, READ, STAD, SKCM, THCA, TGCT, and UCEC; BTN3A1, BTN3A2, CD28, ENTPD1, HMGB1, and TLR4 are the most affected tumor types (Figure 7C). Here, HMGB1 is linked to neoplasm.