CEBPZ and acute myeloid leukemia: Core binding factor-AML (CBF-AML) is defined as the presence of either t (8;21) (q22; q22) or inv (16) (p13q22)/t (16;16) (p13.1; q22) which individually result in the disruption of genes encoding subunits of CBF, a heterodimeric transcription factor essential in normal hematopoiesis [3,4].