XRCC5 and cancer: Kaplan–Meier survival curves comparing the age at CRC diagnosis between genotypes of the XRCC5 rs1051685 SNP differed significantly (comparing AA, AG, and GG; log-rank test p = 0.040), with a 9-year difference in the median age at cancer diagnosis between heterozygous (AG) and wild-type (AA) genotype carriers (Supplementary Figure S4B).