Similarly, to determine the aggregated effect of combined identified protective genotypes identified in the univariate Cox regression analysis for any cancer and CRC (XRCC5 rs1051685 AG, and GSTT1 null genotypes, in Supplementary Tables S4 and S6) on age at cancer diagnosis in LS, we combined individuals carrying one to two protective genotypes into one group (one–two genotypes) [38]. The gene discussed is XRCC5; the disease is cancer.