LSVH carriers of the XRCC5 rs1051685 heterozygous (AG) genotype were more likely to be diagnosed with CRC at an older age than those with the wild-type (AA) genotype (39% estimated risk reduction; Adj HR: 0.61 [CI: 0.41–0.92], p = 0.019) (Supplementary Table S6). This evidence concerns the gene XRCC5 and colorectal carcinoma.