BCL2 and breast carcinoma: In the search for the mechanisms of antiproliferative activity of UA against breast cancer cells, Zuo et al. (2015) found that it induced ROS generation in MCF-7 cells, which triggered the mitochondrial pathway of apoptosis with the activation of c-Jun-N-terminal kinase (JNK), an increase in the Bax:Bcl-2 ratio, a drop in MMP, the release of cytochrome c and caspase cascade activation.