UA also modulated the expression of apoptosis-related genes of the apoptosis pathway in SKBR-3 breast cancer cells with significant elevation of mRNA for caspases 3, 4, 10, TRAF 5 and 6, numerous TNF family members, APAF1, Bik, Bak1, Bax, Bok, MCL1, p53, Chek1, Chek2, DAPK2, RIPK2, GADD45A and reduction in mRNA for Bcl2, Bcl2L11, Bag1, Bag4. This evidence concerns the gene BAX and breast cancer.