The combined expression of PLGF, HIF-1α, VEGFR1 (FLT1 gene), and PD1 was associated with several cancer hallmarks, regardless of cancer type, including tissue invasion and metastasis, sustained angiogenesis, persistent proliferative signaling, immune evasion, and reprogramming of energy metabolism (Figure 5C). This evidence concerns the gene FLT1 and cancer.