Moreover, we studied sGPVI concentrations in the intracranial vasculature within the pial collateral circulation prior to EVT in this cohort as described by [13] to further explore the role of GPVI signaling and shedding in local ultra-early stroke pathophysiology [14] and to assess the utility of sGPVI as an intravascular cerebral biomarker. This evidence concerns the gene GP6 and stroke disorder.