GLE1 and motor neuron disorder: Other processes involved in the pathophysiology of motor neuron diseases include structural and functional abnormalities of mitochondria (SOC2, TK2, DGUOK, and PLAG26), free-radical-mediated oxidative stress, RNA processing (VRK1, EXOSC3, EXOSC8, TSEN54, SLC254A6, MORC2, SMN1, TRIP4, ASCC1, UBA1, GLE1, ERBB3, IGHMBP2, and RBM28), cation-channel-mediated molecular transport (TRPV4), vitamin uptake (SLC52A3 and SLC52A2), nuclear transport (GLE1), lipid metabolism (ASAH1), and axonal transport proteins (BICD2 and DYNC1H1) [19,26,27].