FIG4 and Parkinson disease: Interestingly, Lewy bodies (mostly brainstem-type, but also cortical) in autopsy-proven cases of PD or dementia with Lewy bodies were found to be immunoreactive for FIG4, suggesting that FIG4 may be involved in the development or breakdown of neuronal inclusions related to neurodegeneration [33] However, no evidence of α-synuclein detection in any biological tissues (e.g., skin, cerebrospinal fluid, blood) was reported for any of the 12 cases of FIG4-related parkinsonism.