Moreover, reduced activity of lysosomal cation channels secondary to reduced PI(3,5)P2 was reported to result in osmotic enlargement of the lysosomal compartment and cytoplasmic vacuolization [32] Consequently, FIG4-related parkinsonism seems to align with other neurodegeneration- and parkinsonism-related genes, such as *GBA*, which are associated with protein-degrading processes, like the late endosomal/lysosomal pathway. Here, GBA1 is linked to Parkinson disease.