However, no significant association with obesity was reported for the genetic variants of LEP (A19G), LEPR (K109R, Q223R), PYY (R72T), NPY (rs16147T, rs161139C), PPAR (L162V), PPAR2 (C161T), PPARδ (T294C), UCP1 (-3826 A/G), UCP3 (-55C/T), CARTPT (rs2239670), POMC (Rsal), MC4R (V1031), FTO (rs9930506, rs9939609, rs17817288, rs9930501, rs9932754), ADIPOQ (rs3774261), INSIG2 (rs7566605), RETN, DRD2 (Taq1A, Taq1B, Taq1C), VDR (bsml), IRX (rs3751723), FASN (rs4246445, rs2229425, rs2228305,rs2229422), and ADRB2 (rs1042713). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.