INSIG2 and obesity disorder: However, no significant association with obesity was reported for the genetic variants of LEP (A19G), LEPR (K109R, Q223R), PYY (R72T), NPY (rs16147T, rs161139C), PPAR (L162V), PPAR2 (C161T), PPARδ (T294C), UCP1 (-3826 A/G), UCP3 (-55C/T), CARTPT (rs2239670), POMC (Rsal), MC4R (V1031), FTO (rs9930506, rs9939609, rs17817288, rs9930501, rs9932754), ADIPOQ (rs3774261), INSIG2 (rs7566605), RETN, DRD2 (Taq1A, Taq1B, Taq1C), VDR (bsml), IRX (rs3751723), FASN (rs4246445, rs2229425, rs2228305,rs2229422), and ADRB2 (rs1042713).