However, no significant association with obesity was reported for the genetic variants of LEP (A19G), LEPR (K109R, Q223R), PYY (R72T), NPY (rs16147T, rs161139C), PPAR (L162V), PPAR2 (C161T), PPARδ (T294C), UCP1 (-3826 A/G), UCP3 (-55C/T), CARTPT (rs2239670), POMC (Rsal), MC4R (V1031), FTO (rs9930506, rs9939609, rs17817288, rs9930501, rs9932754), ADIPOQ (rs3774261), INSIG2 (rs7566605), RETN, DRD2 (Taq1A, Taq1B, Taq1C), VDR (bsml), IRX (rs3751723), FASN (rs4246445, rs2229425, rs2228305,rs2229422), and ADRB2 (rs1042713). The gene discussed is UCP1; the disease is Obesity.