However, no significant association with obesity was reported for the genetic variants of LEP (A19G), LEPR (K109R, Q223R), PYY (R72T), NPY (rs16147T, rs161139C), PPAR (L162V), PPAR2 (C161T), PPARδ (T294C), UCP1 (-3826 A/G), UCP3 (-55C/T), CARTPT (rs2239670), POMC (Rsal), MC4R (V1031), FTO (rs9930506, rs9939609, rs17817288, rs9930501, rs9932754), ADIPOQ (rs3774261), INSIG2 (rs7566605), RETN, DRD2 (Taq1A, Taq1B, Taq1C), VDR (bsml), IRX (rs3751723), FASN (rs4246445, rs2229425, rs2228305,rs2229422), and ADRB2 (rs1042713). The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.