Results: The identified gene variants, including LEPR (K656N), LEP (G2548A—Indian only), ADIPOQ (rs17366568), UCP2 (45bp-I/D), ADRB3 (rs4994), MC3R (rs3827103), PPARγ (pro12Ala—Malay only), IL1RA (intron 2 VNTR), NFKB1 (rs28362491), and FADS1 (rs174547—Indian only), showed significant associations with obesity as measured by the respective studies. The gene discussed is MC3R; the disease is obesity due to melanocortin 4 receptor deficiency.