Lopez-Pastor et al. used an apolipoprotein E-deficient HFD-fed mouse model to understand the role of circulating miRNAs in NAFLD progression and identified level increases in miR-27b-3p and miR-122 from EVs in both Apoe−/− HFD and standard diet (SD)-fed mice compared to (SD)-fed WT mice [55]. The gene discussed is APOE; the disease is metabolic dysfunction-associated steatotic liver disease.