In a longitudinal study involving humans that was designed to investigate the risk of dyslipidemia and kidney stone disease, after adjusting for age, sex, smoking and alcohol history, diabetes, hypertension, fasting glucose, albumin, and eGFR, researchers demonstrated that hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), and a high Chol/HDL-C ratio were associated with a higher risk of developing kidney stones [25]. The gene discussed is ALB; the disease is hypertriglyceridemia.