While in the majority of infants with DS, TAM resolves spontaneously, 5 to 10% of them are found to have variants in cohesin, protein CCCTC-binding factor CTCF gene, oncogenes belonging to the RAS family, and genes of the Janus Kinase and Signal Transducer and Activator of Transcription JAK/STAT4 pathway that induce progressing to ML-DS [60,61,62,63]. Here, CTCF is linked to Dravet syndrome.