Deteriorating condition, increasing hypoglycemia, hyponatremia, and hyperkalemia, together with elevated ACTH (>1380 pg/mL), plasma renin activity (>31 ng/mL/h), and low cortisol (<5 ng/mL) prompted the suspicion of adrenal insufficiency (Table 2), which was later confirmed with a 24-h urine steroid profile analysis (Table 3). This evidence concerns the gene POMC and Hyponatremia.