Additionally, it has been shown that CCR5 [54], CCL2 [51,54,75,79,80], CCL3 [58,75,80], CCL5 [54], CCL7 [54], CCL8 [54], and CCL12 [54] spinal mRNA and/or protein levels are elevated in rodent models of diabetic neuropathy (Figure 2), with some displaying sex-related diversity. This evidence concerns the gene CCR5 and diabetic neuropathy.