Homozygous or heterozygous knockout mice for FBXO30 and BPNT1 exhibit phenotypes of metabolic disorders, skeletal abnormalities, and reduced fitness (see MGI, www.informatics.jax.org, accessed on 6 October 2024), indicating that these genes may play roles in TBP fitness and metabolic regulation. This evidence concerns the gene BPNT1 and metabolic disease.