CPA1 and chronic pancreatitis: In the studies published by Hegyi E. and Sahin-Toth M, it was clearly shown that mice carrying the CPA1 p.Asn256Lys mutation developed chronic pancreatitis and the level of tissue damage increased over time; therefore, after three months, the pancreatic tissue was already damaged 15%, after 6 months, the damage covered 20% of the tissues, while after a year, about 30% of the pancreatic tissue was damaged, which indicates a high potential of the CPA1 gene mutation as a factor increasing the risk of chronic pancreatitis [28].