By chemical proteomics for target fishing (data for characterizing of AI-6G by 1H-NMR and 13C-NMR are shown in Supplemental Figure S2), it was indicated that 6-G directly bound to 422 proteins in HF-induced HepG2 cells, including PHKB, SCD, RFK, SOAT2, PRKACG, etc., (a complete list has not been shown due to our future study on the direct targets and other biological activities of 6-G). This evidence concerns the gene PRKACG and hydrops fetalis.