SCD and steatosis: SCD is primarily regulated by high carbohydrate diets, and global SCD knockout significantly alleviates hepatic DNL, global SCD1 knockout significantly alleviates hepatic DNL and steatosis induced by high-carbohydrate high-fat diets in mice, and the beneficial protective effect can be blocked in liver-specific SCD1 knockout mice fed a high fructose with oleate acid supplementation diet [33,36,37,38].