In vitro studies demonstrated that this resulting combination induced p53-mediated apoptosis against GL261 mouse glioblastoma cells and GSCs, whereas the same combination was found to be effective in the repolarization of M2-tumor-associated microglia (M2-type tumor-associated macrophages), thereby further promoting anti-tumor immunity and augmented immune response in vivo. This evidence concerns the gene TP53 and neoplasm.