For example, the use of transferrin conjugation by Lam et al. [84], glutathione by Gaillard, Pieter J., et al. [101], the use of TfRscFv by Ma et al. [124], angiotensin-2 (an LRP-1-specific ligand) by Yuan et al. [122], and use of angiopep-2 and tLyp-1 by Yang et al. [117] are some mentioned approaches that can be further optimized and assessed for their potential for targeted payload delivery in glioblastoma. Here, LRP1 is linked to glioblastoma.