TP53 and breast carcinoma: Ethanol (95%) extract of Chinese propolis has a dose- and time-dependent cytotoxic effect on both MCF-7 (human breast cancer ER(+)) and MDA-MB-231 (human breast cancer ER(-)) cells by inducing apoptosis, regulating the levels of ANXA7, p53, and NF-κB p65, upregulating intracellular ROS, and decreasing mitochondrial membrane potential [15].