The cell-type assignment for each cluster was visualized as feature plots that assessed for the expression of cell type-specific canonical gene markers (Figure 2C), including the following: well-known melanocyte and melanoma marker Pax3 and Etv1 [15] for melanoma cancer cells; Adgre1, the gene coding for F4/80 and Itgam (Cd11b), for myeloid/macrophage cell populations; Cdh11 and Loxl1 for fibroblasts; Cd247 (T-cell receptor T3 zeta chain), and Il2rb for T cells; Cdh5 (VE-cadherin) and Vwf (Von Willebrand factor) for endothelial cells; Flt4 for lymphatic endothelial cells (Figure 2C). The gene discussed is ADGRE1; the disease is melanoma.