Furthermore, as reported in another study, stabilization of TGFB2 mRNA levels by METTL14-mediated m6A modification and then knockdown of TGFB2 mRNA using shRNA found to lower TGFB2 expression decreased gemcitabine resistance in pancreatic cancer cells and increased cell apoptosis. The gene discussed is TGFB2; the disease is familial pancreatic carcinoma.