HLA-DRB1 and cancer: Examining mRNA expression levels in tumors versus normal comparisons (Figure 6B) showed that CD74, a type-II transmembrane glycoprotein which has been shown to function as a chaperone in transporting MHC II molecules involved in antigen presentation [71], was coregulated with HLA-DQB1, HLA-DRB1, and HLA-DRA, and served as a marker for M1-like macrophage infiltration in 32 cancers including PDAC from the TCGA dataset [72].