A study that applied a computational approach to characterize ligand-receptor interactions between macrophages and tumor ductal cells using the CellphoneDB algorithm to interrogate single-cell transcriptomics data showed significant LGALS9-CD44 and LGALS9-MET interactions were correlated with worse overall survival in PDAC TME, and LGALS9 was over-expressed in the macrophage subset [18]. This evidence concerns the gene MET and neoplasm.