Single-cell transcriptomic profiles obtained from resected PDAC primary tumors and matched liver metastases identified a subset of TAMs expressing HLA-DRA, CD74, C1QA mRNA [20] that also exhibited independent prognostic effects with significant interaction terms with TGFB2 mRNA expression in the multivariate models reported in our study (Figure 6A), thereby suggesting cooperation between TGFB2 and this subtype of TAMs in the metastasis of pancreatic cancer cells. This evidence concerns the gene CD74 and familial pancreatic carcinoma.