STAT1 and neoplasm: Components of the type-I interferon signaling pathway exhibited significant upregulation of mRNA levels in tumor tissue: Interferon alpha/beta receptor 1 (IFNAR1; 3.4-fold increase, p < 0.0001), Interferon regulatory factor 9 (IRF9; 4.2-fold increase, p < 0.0001), and Signal transducer and activator of transcription 1 (STAT1; 7.1-fold increase, p < 0.0001) (Table S1).