Vitisin A, a resveratrol tetramer derived from the stembark of V. vinifera, exhibited significant neuroprotective effects by mitigating H2O2-induced cytotoxicity in SH-SY5Y cells and alleviating scopolamine-induced cognitive deficits in rodent models in behavioral assessments, through the upregulation of BDNF-CREB signaling and long-term potentiation [150]. Here, BDNF is linked to Cognitive impairment.