Furthermore, treatment with A. senticosus in the 5xFAD transgenic AD model significantly ameliorated learning and memory deficits, accompanied by the reversal of mRNA expression of APP, NTRK1, EGFR, ESR2, GSK3B, PAK1, and the MAPK signaling pathway in the hippocampus [183]. Here, GSK3B is linked to Alzheimer disease.