Preventing anxiety, cognition, and motor coordination (NOR, EPM, and Rotarod test)Protecting hippocampal neurodegeneration and impaired synaptic plasticity (increasing MAP2, PSA-NCAM, Bcl-xL expression)Upregulating ERK and AKT pathways in the hippocampusReducing pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6). This evidence concerns the gene AKT1 and Anxiety.