Arraud et al. [17] and Connor et al. [18] reported that, respectively, 50% or 20% of platelet-derived microvesicles in healthy donors bind annexin V. It complies with our previous [15,19] and current findings performed with a dedicated cytometer, indicating that the proportion of %PS+pEVs is even lower (9–12% in stroke patients, 7% in DCs, and 8% in HCs). Here, ANXA5 is linked to stroke disorder.