Coupled NaCl absorption occurs via the functional coupling of villus cell brush border membrane (BBM) Na:H exchange (NHE3, sodium–hydrogen exchanger 3/SLC9A3) and Cl:HCO3 exchange (DRA, downregulated in adenoma/SLC26A3 and PAT1, putative anion transporter-1/SLC26A6) [10]. The gene discussed is SLC26A3; the disease is adenoma.