Since it is being increasingly recognized that genetic variations that disturb enhancer functionality can cause brain disorders, we strongly suggest identifying and screening the enhancers of other SCA genes, in particular for those genes with known variants within the regulatory regions (DAB1, PPP2R2B, and ATXN8OS), to explain a fraction of missing genetic diagnoses for SCA patients. This evidence concerns the gene DAB1 and autosomal dominant cerebellar ataxia.