GFAP and Alexander disease: Likewise, the natural polyphenolic compound curcumin has the ability to inhibit GFAP misfolding in an in vitro model of AxD [10], α-syn misfolding in experimental models of PD [109,110,111], and amyloid beta oligomers formation and interactions with anionic membranes in experimental models of Alzheimer’s disease [112,113].