Hyperglycemia also affects multiple pathways other than NF-κB, including JAK/STAT, PKC, AGE, MAPK, and TLR signaling, which together lead to the over-production of pro-inflammatory cytokines like IL-6, IL-1β, and TNF-α, ultimately leading to inflammation and tissue damage [21]. This evidence concerns the gene NFKB1 and Hyperglycemia.