CDKN1C and rigid spine muscular dystrophy 1: Subsequently, CDKN1C mutations were found to be involved in the pathogenesis of two other growth-related syndromes, such as IMAGe (Intrauterine growth restriction, Metaphyseal dysplasia, Adrenal hypoplasia congenita, and Genital anomalies) and Russell–Silver syndrome (RSS), consolidating the idea of the key role of p57 during embryonic development and in the homeostasis of tissues/organs expressing the protein [10,11,12,13].