FBN1 and myeloid sarcoma: In the other four patients diagnosed with MS, who came from different, unrelated families, new variants of FBN1 were also detected (Table 1, Figure 2) The family history of aortic disease (aortic dilation and/or dissection) was positive in six of the ten analyzed patients (P01, P02, P03, P04, P05, and P06), all being diagnosed with MS.