Moreover, changes in the expression of genes in microglia were correlated with several identified DEGs in endothelial cells, including Fkbp5, which impacts microglia polarization [50]; Picalm, which has been linked with AD development and regulation of the immune system [51]; and Mef2a, which has been associated with AD pathogenesis [52]. This evidence concerns the gene PICALM and Alzheimer disease.