MAPK8 and obesity due to melanocortin 4 receptor deficiency: Using hierarchical clustering, comparison of expression profiles of genes involved in this pathway showed that Rasgrf1, Tnr, Pak3, Mapk10, Pdgfa, Pip5k1c, Ppp1r12c, Mapk8, and Src genes were upregulated by obesity in endothelial cells, whereas downregulated in the other cell types, suggesting that even though DEGs were involved in a similar cellular process, there was cell specificity leading to distinct expression profiles.