Recent research has shown that TIM-3 promotes tumor progression through a variety of mechanisms, including facilitating tumor cell migration and invasion, directly suppressing CD4+ T cells by activating the IL-6-STAT3 pathway to prevent Th1 polarization, and stimulating the mTOR function in acute myeloid leukemia (AML) cells [21]. Here, STAT3 is linked to acute myeloid leukemia.